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Afro-Egypt J Infect  Endem  Dis  2018 September ; 8(3):149

Brucellosis Relapse: A Retrospective Study of Risk Factors among Saudi Patients

Elsayed Saad Abd elbaser1 and Heba A. Mohammed2

Departments of Tropical Medicine1 and Microbiology and Immunology2, Faculty of Medicine, Zagazig University, Zagazig, Egypt



Background and study aim: Brucellosis is one of the most common zoonotic infections worldwide. Brucella organisms are able to survive and even multiply within mononuclear cells explaining the tendency of the disease to have a prolonged clinical course and relapse. The incidence of relapse in Brucellosis remains high; ranging from 5-30% of patients. The aim of this study is to evaluate possible risk factors of Brucellosis relapse.

Patients and Methods: A retrospective study of 127 patients was conducted to evaluate risk factors of Brucellosis relapse. The diagnosis of relapse was based on recurrence of clinical picture within 3-6 months from treatment, increase agglutinating antibody titers and PCR. Different demographic, clinical, laboratory and serological parameters were studied based on the data gathered from the patients` electronic files.

Results: Out of 127 patients, 21 (16.5%) patients were diagnosed as relapsers. No significant differences were found between relapsed and non-relapsed patients regarding age, sex, residence, clinical features, complications, lymphocytic count and serological titers. As regard treatment, regimens included Streptomycin and Doxycycline had a significant decrease in relapse occurrence.

Conclusion: Anti-microbial regimen included Streptomycin and Doxycycline is the only preventive factor for Brucellosis relapse.