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Afro-Egypt J Infect  Endem  Dis  2018 September ; 8(3):140

Serum Resistin Level as a Diagnostic Marker in Non-Alcoholic Steatohepatitis

Sameh M. Abdel Monem1, Talaat Fathy1, Sally M. Shalaby2and Essam A. Wahab3                                             Tropical Medicine1, Biochemistry2 and Internal Medicine3 Departments, Faculty of Medicine, Zagazig University, Egypt



Background and study aim: Non-alcoholic fatty liver disease (NAFLD) is a state defined by extreme fat accumulation in the form of triglycerides (steatosis) in the liver. A subgroup of NAFLD patients characterized by injury to the hepatocytes and inflammation in addition to excessive fat, the latter condition, nominated non-alcoholic steatohepatitis (NASH). The work aimed to evaluate the role of serum resistin level as a diagnostic marker in patients with non-alcoholic steatohepatitis who were admitted to the Tropical Medicine and Internal Medicine departments, Faculty of Medicine, Zagazig University (inpatient and outpatient).

Patients and Methods: This study was performed on 38 patients between April 2017 to May 2018.They were classified into two groups; control group included 19 non-obese apparently healthy individuals, 11 males and 8 females with average age of 43.2 year and average body mass index of 23.46 Kg/m2 and patients group  included 19 patients with NASH, 13 males and 6 females with average age of 44 year and average body mass index of 32.71 Kg/m2. They had  bright fatty liver on ultrasono-graphic examination and raised ALT and AST and liver biopsy  confirmed the diagnosis of NASH. Clinical assessment, laboratory evaluation, pelvi-abdominal ultrasound, and serum resistin were done for all participants.

Results: In this study: Cut off level of serum resistin was >3.7 ng/ml and there was a significant difference as regard serum resistin in NASH group in comparison with control group.

Conclusion: Serum resistin level was significantly higher among NASH group in comparison to the control group. Serum resistin level  may be a good diagnostic marker for patients with NASH.