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Afro-Egypt J Infect  Endem  Dis  2017 December ; 7(4):238

Study of the Correlation between Serum Testosterone Level and Sarcopenia in Egyptian Male Patients with Liver Cirrhosis

 Atef Abo Alsood Ali1, Naglaa Said El Abd1, Shaimaa Abd El-Hamid Abd El Mageed2, Mostafa Ibrahim Al Goghop3

1Tropical Medicine Dept., Faculty of Medicine, Menoufia University, Menoufia, Egypt      2Diagnostic Radiology Dept., Faculty of Medicine, Menoufia University, Menoufia, Egypt                                                                   3Hepatology Dept., Al haram Specialized Hospital, Cairo, Egypt



Background and study aim: Irrespective of etiology, liver cirrhosis together with its complications can affect other body organs and lead to a great morbidity and mortality. In Cirrhotic patients, Sarcopenia block normal life activities. Low serum testosterone has been reported in up to 90% of men with liver cirrhosis. This study aimed to assess the correlation between serum testosterone level and sarcopenia in Egyptian male patients with liver cirrhosis.

Patients and Methods: This prospective study included sixty cirrhotic males. Three groups were designed according to Child-Pugh classification. Twenty healthy males were included as control group. Patients and controls were subjected to complete blood picture, liver and kidney functions. Serum total & free testosterone was analyzed by specific enzyme-linked immunosorbent assay (ELISA) kit and Skeletal Muscle Index (L3 SMI) was assessed by CT scan.

Results: There was significant decrease in serum levels of free and total testosterone in cirrhotic patients than controls, with lowest levels in child C cirrhotic males (p value <0.001). 32 (53.3%) cirrhotic patients were sarcopenic‏.‏ At cutoff point 14.1 nmol/L total testosterone level has Sensitivity 91%, Specificity 94% and Accuracy 93.0% to predict sarcopenia in cirrhotic males with AUC = 0.938. There was significant positive correlation between total testosterone level and the L3 SMI (r= 0.819, P<0.001). In addition, a positive correlation was detected between total testosterone and hemoglobin (r= 0.668, P<0.001), serum Na (r= 0.846, P<0.001) and Platelet count (r= 0.904, P<0.001), also negative correlation with MELD score (r= - 0.928, P<0.001).

Conclusion: Significant positive correlation between total testosterone level and Skeletal Muscle Index (L3 SMI) and low testosterone level is associated with sarcopenia in cirrhotic males.