Evaluation of Cirrhotic Cardiomyopathy related Parameters in Child’s C Patients With and without Adrenal Insufficiency

Article 1, Volume 9, Issue 4, December 2019, Page 242-251 

Document Type: Original Article

DOI: 10.21608/AEJI.2019.15947.1033

Authors

Amal Abdelhamid Gad  ¹; Fawzy Attia¹; Hanan Kamal²; Naglaa Salam³; Nashaat Hawass⁴

¹Internal Medicine Department,Faculty of Medicine ,Suez Canal University ,Egypt.

²Cardiology Department,Faculty of Medicine ,Suez Canal University ,Egypt.

³Clinical Pathology Department,Faculty of Medicine ,Suez Canal University ,Egypt.

⁴Endemic and Infectious Diseases Department ,Faculty of Medicine ,Suez Canal University ,Egypt.

Abstract

Background and Aim: The association between cirrhotic cardiomyopathy (CCM) and adrenal insufficiency (AI) is still not well declared. We aimed to study the association between CCM related echocardiographic (ECHO) parameters and AI in patients with advanced liver cirrhosis.
Patients and Methods: A cross sectional study was carried out on 60 adult patients with advanced liver cirrhosis (Child’s C) who showed a low ejection fraction (EF) of Results: The mean age was 63.83±7.64 with male sex predominance (87.4%). Their mean EF was 39.17±7.34, while 88.4% of them had a high LVEDD with a mean of 62.31±10.21 mm. The mean morning fasting free serum cortisol level was 7.95±5.23 mcg/dl with 48.4% of them having AI. Comparison of those with and without AI showed that the former group had a higher LAD (43.26±10.04 vs 42.76±7.64), LVESD (50.83±10.66 vs. 48.08±8 .17) and LVEDD (64.83±9.95vs. 59.94±9.97)) respectively. However, the difference was not statistically significant (P>0.05). There was no significant correlation between any of the CCM parameters or those of hepatic decompensation and the fasting serum cortisol level among the studied group (P>0.05).
Conclusion: There was no significant correlation between AI and any of the selected parameters related to CCM.

Keywords

cirrhosis; cardiomyopathy; Glucocorticoids

Main Subjects

Hepatology