Afro-Egypt J Infect Endem
Dis 2016 March ; 6(1):7
The
Fibrosis-Cirrhosis Index (FCI) for Staging of Liver Fibrosis in Chronic
Hepatitis C
Younis YS , Baiomy HA,El-Shawaf IM,Said EM,Eisa
AI
Hepatology,
Gastroenterology and Infectious Diseases Department, Faculty of Medicine,Benha
University,Benha ,Egypt.
Dr.amr3esa@yahoo.com
ABSTRACT
Background
and study aim :
Chronic
hepatitis C (CHC) is a major global health problem with its consequences of
liver fibrosis and cirrhosis. Liver fibrosis is the main predictor of the
progression of chronic hepatitis C, and its assessment
can help determine therapy. Several indices
are available to predict cirrhosis. The fibrosis – cirrhosis index (FCI) was
proposed to be efficient for none invasive staging of liver fibrosis besides
being simple and inexpensive. This study is designed to assess the accuracy of
the fibrosis-cirrhosis index (FCI) for non-invasive staging of liver fibrosis in
patients with chronic hepatitis C compared to the liver biopsy findings.
Patients
and methods:
This study
was conducted on 150 chronic hepatitis C patients who attended the Hepatology,
Gastroenterology and Infectious Diseases Department at Benha University Hospital
and El Mansoura Health-Insurance Hospital.
Another group of 30 healthy subjects (with negative hepatitis viral markers)
represented the control group.
Results:
FCI was a relatively sensitive, specific and accurate marker of fibrosis. At a
cutoff value of < 0.12, FCI had a NPV of 81.7% for the exclusion of significant
fibrosis, while at cutoff value > 0.19 it had a PPV of 82.5% for the diagnosis
of advanced fibrosis.
Conclusion:
FCI is a simple index that integrates ALP, bilirubin, albumin and platelet count
for staging fibrosis from absent up to cirrhosis.